2. Epilepsy and Neural Network Dynamics: Understanding and Intervening

Epilepsy offers a unique lens through which to study how neural networks change and adapt—or fail to adapt—over time. Building on a foundation of longstanding collaborations and prior work in the field, our lab investigates the progression of neocortical network activity during epileptogenesis, the process by which a brain becomes susceptible to recurring seizures.

Some of the key questions we aim to answer include:
I. How do neocortical neural activity patterns, connectivity, and information processing evolve during the onset of epilepsy?
II. What mechanisms contribute to the transition from normal brain function to a state of chronic seizures?

We use kindling models to induce and study neocortical epileptic activity in rodent models. Kindling allows us to gradually increase the brain’s susceptibility to seizures, providing a controlled way to examine changes in network dynamics. Our work includes testing innovative therapeutic approaches, including pharmacological interventions and electrophysiological techniques, to halt or reverse the progression of epilepsy.

By integrating our studies of brain states and network dynamics, the Liou Lab seeks to contribute to the understanding of brain function and dysfunction. Through our research, we aim to open new avenues for treating complex neurological and psychiatric conditions, from sleep disorders to epilepsy.